POF is a condition where the number of eggs in a woman's body has been reduced significantly or the follicles are not responding to hormonal stimulation. This problem affects one in every 1,000 women between the ages of 15 and 29 and one in every 100 between the ages of 29 and 39. In such cases, there is a marked reduction in estrogen production, the follicles don't produce mature eggs, and the endometrium is too thin for proper implantation.
Signs and symptoms of POF include shorter cycles (usually with no ovulation) or inconsistent periods (skipping a month here and there). Menopausal symptoms such as hot flashes and vaginal dryness may manifest as well.