Sports injuries. In a 2010 study, 101 patients with ankle sprain were given either the standard therapy of Protection, Rest, Ice, Compression, and Elevation (PRICE), or PRICE plus early therapeutic exercise during the first week after the sprain. The group that included exercise had improved ankle function during the first week and into the second week. For knee injuries, the McConnell multimodal physiotherapy regimen has been shown to be effective. This regimen includes stretching, mobilization, massage, balance training, and general conditioning.